Early faecal excretion of inhaled plutonium.

Effects of Early Administration Times of Injected Ca-DTPA on Removal of Inhaled Plutonium Nitrate in Rats

INTRODUCTION The crucial moment of Ca-DTPA (calcium salt-diethylenetriaminepentaacetic acid) therapy for the removal of inhaled plutonium is the timing of the first injection. This is because DTPA acts on plutonium while it is in the blood, this action is lost after plutonium has been deposited into the organs. It is, therefore, generally accepted that chelation therapy should be started as ear...

Plutonium fecal and urinary excretion functions: derivation from a systemic whole-body retention function.

Liver-bile secretion directly influences the content of plutonium in feces. To assess the reliability of plutonium metabolic models and to improve the accuracy of interpreting plutonium fecal data, we developed a compartmental model that simulates the metabolism of plutonium in humans. With this model, we can describe the transport of plutonium contaminants in the systemic organs and tissues of...

Determination of plutonium in human feces.

The toxic effects of plutonium on the human body depend on a considerable number of physical and biological factors. One of the most important biological factors is the rate of elimination of plutonium from the body. The ratio of fecal to urinary excretion of plutonium by the rat is of the order of 10: 1. This is, indeed, a favorable ratio. Preliminary information, however, indicates that the e...

Evaluation of Internal Exposure to Plutonium from the Late Urinary Excretion Data

Threshold for Radon-Induced Lung Cancer From Inhaled Plutonium Data

Cohen's lung cancer mortality data, from his test of the LNT theory, do not extend to the no observed adverse effects level (NOAEL) above which inhaled radon decay products begin to induce excess lung cancer mortality. Since there is concern about the level of radon in homes, it is important to set the radon limit near the NOAEL to avoid the risk of losing a health benefit. Assuming that dogs m...